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71 these results suggest that overall the p16 ink4a gene is more responsible in inducing cellular senescence and tumor suppression in human cells interestingly the ink4aarf locus is known to be repressed by the polycomb proteins b lymphoma mo mlv insertion region 1 bmi 1 and related family members in both human and mouse cellscellular senescence and tumor suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions with a particular emphasis on the role of senescence in tumor suppression show all table of contents 10 chapterstakeuchi s takahashi a motoi n yoshimoto s tajima t et al intrinsic cooperation between p16 ink4a and p21 waf1cip1 in the onset of cellular senescence and tumor suppression in vivo cancer res 2010 70938190it was reported that oncogenic ras induces dna damage signaling and the activation of the cell cycle checkpoint which are critical for the cellular senescence and tumor suppression phenotypes 4042 therefore we have examined h2ax foci formation a dna damage response marker in tumors in all the genotypes h2ax foci were detectable presscom your medical bookshop shop by category registration login view basket eshop exhibitions publishers

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